Effects of nutrition intervention on total and cancer mortality: 25-year post-trial follow-up of the 5.25-year Linxian Nutrition Intervention Trial

SM Wang, PR Taylor, JH Fan, RM Pfeiffer… - … the National Cancer …, 2018 - academic.oup.com
… was conducted in Linxian, China, from 1986 to 1991; 29 584 … effects of nutritional interventions
on cancer prevention, but few … because it was the first randomized, double-blind, placebo-…

[HTML][HTML] Role of beta-carotene in lung cancer primary chemoprevention: a systematic review with meta-analysis and meta-regression

J Kordiak, F Bielec, S Jabłoński… - Nutrients, 2022 - mdpi.com
… However, this study focuses solely on lung cancer, being a leading problem among cancer
… Only one trial conducted in China [20] suggested that beta-carotene supplementation had …

Carotenoids for lung cancer chemoprevention and chemotherapy: promises and controversies

R Varghese, T Efferth, S Ramamoorthy - Phytomedicine, 2023 - Elsevier
… For instance, a 7-year long investigation was performed in Chinese men through … It
was a randomized, double-blind study conducted in more than 29,000 male smokers with …

Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial

WQ Li, JY Zhang, JL Ma, ZX Li, L Zhang, Y Zhang… - bmj, 2019 - bmj.com
… by the Chinese Center for Disease Control and Prevention, which … The Linxian Nutrition
Intervention Trial showed a durable … Randomized double-blind factorial trial of three treatments to …

Cancer prevention and control: alarming challenges in China

AM Bode, Z Dong, H Wang - National science review, 2016 - academic.oup.com
China's toxic air pollution levels are likely to be a major contributor to the increased lung
cancer rates; however, most lung cancers in China are still attributable to cigarette smoking. …

[HTML][HTML] … in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial

HD Sesso, PM Rist, AK Aragaki, S Rautiainen… - The American Journal of …, 2022 - Elsevier
… We performed a randomized, double-blind, placebo-… We observed a protective effect of a
daily MVM on lung cancer (HR: … The Linxian trial tested a combination of β-carotene, vitamin E, …

… long‐term effect of nutrition intervention in the Linxian Dysplasia Nutrition Intervention Trial and the reason for disappearance of the intervention effect: A cohort study

J Fan, W Sun, H Yang, X Wang, CC Abnet, Y Qiao - Cancer, 2023 - Wiley Online Library
… had an adverse effect on lung cancer incidence and mortality, which was … study because it
was the first randomized, double-blind, placebo-controlled nutritional intervention trial in China

Natural products for cancer prevention: clinical update 2016

K Sanders, Z Moran, Z Shi, R Paul… - Seminars in oncology …, 2016 - Elsevier
… In the 1980s and 1990s, intervention trials in Linxian, China … Women's Health Study showed
that risk of lung cancer was … (Canada) Randomized, double-blind placebo controlled trial. …

Lessons learned from cancer prevention studies with nutrients and non‐nutritive dietary constituents

CS Yang, JX Chen, H Wang… - Molecular nutrition & food …, 2016 - Wiley Online Library
… was also demonstrated in another study in Linxian. In a … of skin cancer, a multicenter,
double-blind, randomized, placebo… -T in inhibiting cancer cell growth in culture, human lung

[HTML][HTML] Assessing the current state of lung cancer chemoprevention: a comprehensive overview

M Ashraf-Uz-Zaman, A Bhalerao, CM Mikelis, L Cucullo… - Cancers, 2020 - mdpi.com
… effort in the area of lung chemoprevention is required to develop … in clinical trials targeting
lung cancer chemoprevention in various … , double-blind nutrition intervention trials in China: the …